Wednesday, October 22, 2025

๐ŸŒฟ Astragalus Polysaccharides Shield Against Chemical-Induced Testicular Damage by Reducing Oxidative Stress and Regulating the PI3K/Akt/mTOR Pathway #sciencefather #researcherawards #health

 ๐ŸŒฟ Astragalus Polysaccharides Protect Testicular Health

๐Ÿงฌ Introduction

Exposure to harmful chemicals like Di-n-butyl phthalate (DBP) can cause severe testicular damage, oxidative stress, and reproductive issues. Researchers have explored natural compounds such as Astragalus polysaccharides (APS) for their ability to protect reproductive health and prevent toxicity.

⚗️ Protective Power of Astragalus Polysaccharides

Astragalus polysaccharides, extracted from the traditional medicinal herb Astragalus membranaceus, are known for their strong antioxidant and anti-inflammatory effects. In recent studies, APS significantly reduced oxidative stress in rat testes exposed to DBP, helping to maintain normal cell function and tissue structure.

๐Ÿ”ฌ Mechanism of Action

APS works by modulating the PI3K/Akt/mTOR signaling pathway, a critical regulator of cell survival and metabolism. This modulation prevents apoptosis (cell death) and restores normal testicular activity, demonstrating how natural molecules can help balance cellular pathways disrupted by chemical exposure.

๐ŸŒฑ Conclusion

The findings reveal that Astragalus polysaccharides offer a promising natural defense against chemical-induced reproductive toxicity. Their ability to reduce oxidative damage and support cellular recovery makes them a potential therapeutic agent for protecting male reproductive health.

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